|Tested species reactivity||Bovine, Human, Sheep, Pig|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||IM-9 lymphocytes followed by purified insulin receptor|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Inhibition Assays (IA)||10nM|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-13773 targets Insulin Receptor alpha in IA applications and shows reactivity with Bovine, Human, Ovine, and Porcine samples.
The MA5-13773 immunogen is iM-9 lymphocytes followed by purified insulin receptor.
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide-linked subunits in a beta-alpha-alpha-beta configuration. The beta-subunit (95kDa) possesses a single transmembrane domain with tyrosine kinase activity, whereas the alpha-subunit (135kDa) is completely extracellular.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity.
MA5-13773 was used in blocking or activating experiment to study the effect of extracellular PBEF/NAMPT/visfatin on pro-inflammatory signalling in human vascular smooth muscle cells and its mechanism
|Romacho T,Azcutia V,Vázquez-Bella M,Matesanz N,Cercas E,Nevado J,Carraro R,Rodríguez-Mañas L,Sánchez-Ferrer CF,Peiró C||Diabetologia (52:2455)||2009|
The release of the adipocytokine visfatin is regulated by glucose and insulin.
MA5-13773 was used in blocking or activating experiment to study the role of glucose and insulin in regulating the release of the adipokine visfatin
|Haider DG,Schaller G,Kapiotis S,Maier C,Luger A,Wolzt M||Diabetologia (49:1909)||2006|
Functional insulin receptors on human epithelial ovarian carcinoma cells: implications for IGF-II mitogenic signaling.
MA5-13773 was used in blocking or activating experiment to study the role of functional insulin receptors on human epithelial ovarian carcinoma cells
|Kalli KR,Falowo OI,Bale LK,Zschunke MA,Roche PC,Conover CA||Endocrinology (143:3259)||2002|
A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts.
MA5-13773 was used in western blot to investigate the effect of the humanized anti-IGF-IR antibody h7C10 on anticancer activity of other therapeutics
|Goetsch L,Gonzalez A,Leger O,Beck A,Pauwels PJ,Haeuw JF,Corvaia N||International journal of cancer (113:316)||2005|