|Tested species reactivity||Dog, Human, Mouse, Pig|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Synthetic peptide corresponding to residues C Q(56) E N P I Y K S P I N N F K N P N Y G R K A G L(79) of mouse integrin beta 1D.|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:25-1:200|
|Western Blot (WB)||1:100-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-06906 detects integrin beta-1D in human, canine, porcine and mouse samples.
MA1-06906 has sucessfully been used in immunocytochemistry, immunohistochemistry, and Western blotting procedures.
The MA1-06906 immunogen is a synthetic peptide corresponding to the residues C Q(56) E N P I Y K S P I N N F K N P N Y G R K A G L(79) of the cytoplasmic domain of mouse integrin subunit b1D.
Store at 4°C or in small aliquots at -20°C.
Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. There are two major forms of integrin beta1: beta1A and beta1D, which differ in 13 amino acids. Their distribution pattern in adult tissues is mutually exclusive. beta1A is present in all tissues, except cardiac and skeletal muscle, which instead express the beta1D variant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.