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KNT1 (T-Kinninogen 1) is the acute phase kininogen of the rat. KNT1 could be a healing protein because of its properties as a cysteine protease inhibitor. Evidence has been presented that mRNA of T-kininogen synthesis may be a function of interleukin 6 production. In rats, four types of kininogens are produced, two of which are classical high and low molecular weight kininogens and two of which are low molecular weight-like kininogens, designated T-kininogen 1 and T-kininogen 2. T-kininogen 1 and T-kininogen 2 are 430 amino acid secreted rat proteins that each contain three cystatin domains and have nearly identical functions. Existing in plasma, both T-kininogen 1 and T-kininogen 2 are glycoproteins that act as thiol protease inhibitors and also play a role in blood coagulation, specifically by helping to optimally position blood coagulation factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-1-MAP; low molecular weight (LMW) T-kininogen II; Major acute phase protein; major acute phase protein (alpha-1-MAP); T-kininogen 2; T-kininogen II; T-Kinninogen 1; Thiostatin
Gene Aliases: kininogen
UniProt ID: (Rat) P08932
Entrez Gene ID: (Rat) 288001
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