This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA5-13110 targets Ku (p70) in immunofluorescence, immunohistochemistry (paraffin), immunoprecipitation, FACS and Western blot applications and shows reactivity with Human, Non-human primate, and Xenopus laevis samples. Reacts with mouse and hamster in Western blot applications only.
The MA5-13110 immunogen is human placental extract designated as PSE1-PL.
Antibodies to this protein (and modification) were previously sold as part of a Thermo Scientific Cellomics High Content Screening Kit. This replacement antibody is now recommended for researchers who need an antibody for high content cell based assays. It has been thoroughly tested and validated for cellular immunofluorescence (IF) applications. Further optimization including the selection of the most appropriate fluorescent Dylight conjugated secondary antibody may have to be performed for your high content assay.
The Ku autoantigen is a heterodimer of 70kDa (p70) and ~80kDa (p80) proteins. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase that phosphorylates certain transcription factors, including Sp1, Oct-1, p53, and SV40 large T antigen in vitro. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 5'-dRP/AP lyase Ku70; 70 kDa subunit; 70 kDa subunit of Ku antigen; 70kDa; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Ku autoantigen; Ku autoantigen p70 subunit; Ku autoantigen protein p70 homolog; Ku autoantigen, 70kDa; Ku p70; Ku70; Lupus Ku autoantigen protein p70; thyroid; thyroid autoantigen 70 kDa; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6
Gene Aliases: 70kDa; CTC75; CTCBF; G22P1; KU70; ML8; TLAA; XELAEV_18023498mg; XRCC6