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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG|
|Immunogen||Recombinant antigen containing the amino terminal portion of human Ku80 protein|
|Storage buffer||PBS, pH 7.4|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000-1:5000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-23314 detects Ku80 in Human samples.
MA1-23314 has been successfully used in Western Blot procedures.
MA1-23314 immunogen corresponds to Recombinant antigen containing the amino terminal portion of human Ku80 protein.
Originally identified as an autoantigen, the Ku protein are nuclear proteins found in eukaryotes. They exist as a heterodimer consisiting of Ku 70 and Ku 80, migrating at approximately 70 and 80 kDa respectively. They bind to DNA ends at double strand breaks. The Ku proteins interact with the DNA-dependent protein kinase (DNA-PK) and participate in the targeting of DNA-PK to DNA. The Ku proteins may participate in numerous cellular processes, including DNA repair and replication, cell signalling, cell proliferation, transcriptional activation and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; FLJ39089; KARP-1; KARP1; Ku autoantigen, 80kDa; KU80; Ku86 autoantigen related protein 1; KUB2; lupus Ku autoantigen protein p86; NFIV; nuclear factor IV; thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
G22P2; KARP-1; KARP1; KU80; Ku86; KUB2; NFIV; XRCC5