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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 328 and 598 of Human L-Plastin|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-30078 targets L-Plastin in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30078 immunogen is recombinant protein fragment corresponding to a region within amino acids 328 and 598 of Human L-Plastin.
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); CP64; epididymis secretory protein Li 37; L-PLASTIN; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); LCP-1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; plastin-2; PLS2
CP64; HEL-S-37; L-PLASTIN; LC64P; LCP1; LPL; PLS2