MA1-40130 detects LBP from human samples.
MA1-40130 has been successfully used in ELISA,functional assays and immunoprecipitation applications. ELISA: monoclonal antibody 1C7 can be used both as coating and as detector.
The MA1-40130 immunogen is the LPS binding site on LBP.
Endotoxin <24 EU/mg.
The LBP protein is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BPI fold containing family D, member 2; LBP; Lipopolysaccharide-binding protein; LPS-binding protein
Gene Aliases: BPIFD2; LBP
UniProt ID: (Human) P18428
Entrez Gene ID: (Human) 3929