|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified alpha2 macroglobulin receptor.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||1/50-1/100|
|Immunofluorescence (IF)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay dependent (Non-redu|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
MA1-80192 recognizes human CD91, a type I membrane protein which is also known as alpha-2 macroglobulin receptor (alpha2 MR). MA1-80192 recognizes an epitope in the extracellular region of the 500kD alpha chain.
A suggested positive control for immunohistochemical applications is liver. Non-reducing conditions are recommended for Western blot applications. For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The significance of heat-shock protein gp96 and its receptors' CD91 and Toll-like receptor 4 expression at the maternal foetal interface.
MA1-80192 was used in immunohistochemistry to study the expression of gp96, CD91 and TLR4 at the maternal-fetal interface and the clinical significance
|Gulic T,Laskarin G,Redzovic A,Eminovi¿ S,Haller H,Rukavina D||American journal of reproductive immunology (New York, N.Y. : 1989) (70:10)||2013|