In direct ELISAs, this antibody shows approximately 50-60% cross-reactivity with recombinant human (rh) LRP-6 and no cross-reactivity with rhLDL R.
Reconstitute at 0.5 mg/mL in sterile PBS.
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: crooked; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6
C030016K15Rik; Cd; Gw; Lrp6; ska26; ska
UniProt ID: (Mouse) O88572
Entrez Gene ID: (Mouse) 16974