This antibody specifically recognizes LXR alpha but does not recognize human LXR beta.
Liver X receptors (LXRs), also known as RLD1, are oxysterol activated nuclear receptors which are involved in the regulation of genesis and metabolism of cholesterols and bile acids. LXRs form heterodimeric complexes with the retinoic acid receptors (RARs) once activated by their respective oxysterol ligands. Two known isoforms, alpha and beta, are differentially expressed; the alpha isoform predominantly expressed in liver, whereas beta isoform expression has been shown to be ubiquitous.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: liver X nuclear receptor alpha variant 1; Liver X receptor alpha; LXR-a; LXRA; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha; RLD-1
Gene Aliases: LXR-a; LXRA; NR1H3; RLD-1
UniProt ID: (Human) Q13133
Entrez Gene ID: (Human) 10062