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|Tested species reactivity||Human, Rat|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with E.coli-expressed recombinant human LXR-alpha (164-447 aa).|
|Purification||Ammonium sulfate precipitation|
|Storage buffer||physiological saline|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Liver X receptors (LXRs), also known as RLD1, are oxysterol activated nuclear receptors which are involved in the regulation of genesis and metabolism of cholesterols and bile acids. LXRs form heterodimeric complexes with the retinoic acid receptors (RARs) once activated by their respective oxysterol ligands. Two known isoforms, alpha and beta, are differentially expressed; the alpha isoform predominantly expressed in liver, whereas beta isoform expression has been shown to be ubiquitous.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
liver X nuclear receptor alpha variant 1; liver X receptor alpha; LXR-a; LXRA; nuclear orphan receptor LXR-alpha; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD-1
LXR-a; LXRA; LXRalpha; NR1H3; RLD-1