Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
This antibody detects RYK in human, mouse, and rat samples.
MA1-615 has been successfully used in Western blot, procedures. By Western blot this antibody detects the RYK receptor-like tyrosine kinase-1 in cells.
The MA1-615 immunogen corresponds to the ovalbumin-conjugated synthetic peptide C (462) L T E F H A A L G A Y V(475).
RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ERK3; growth factor receptor; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; Kinase VIK; Met-related kinase; NYK-R; Tyrosine-protein kinase RYK
Gene Aliases: AW536699; D3S3195; ERK-3; JTK5; JTK5A; Mrk; RYK; RYK1; Vik
UniProt ID: (Human) P34925, (Mouse) Q01887
Entrez Gene ID: (Human) 6259, (Rat) 140585, (Mouse) 20187
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support