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MA1-90305 detects RB1 from mouse, human samples.
MA1-90305 has been successfully used in immunohistochemistry (frozen tissue) and Western blot applications, where a band of 111.4 kDa is predicted to be determined.
The MA1-90305 immunogen is considered to be commercially sensitive.
Store at 4°C short term; for long term storage, store at -20ºC, avoiding freeze/thaw cycles.
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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