Product References
ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway.
Oncogene
Rajapaksa G,Nikolos F,Bado I,Clarke R,Gustafsson JÅ,Thomas C
MA3-011 was used in immunoprecipitation and western blot to determine if ERbeta regulates the unfolded protein response.
Thu Jul 30 00:00:00 EDT 2015
ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway.
Oncogene
Rajapaksa G,Nikolos F,Bado I,Clarke R,Gustafsson JÅ,Thomas C
MA3-011 was used in immunoprecipitation and western blot to determine if ERbeta regulates the unfolded protein response.
Thu Jul 30 00:00:00 EDT 2015
Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1.
The Journal of biological chemistry
Belova L,Brickley DR,Ky B,Sharma SK,Conzen SD
MA3-011 was used in immunoprecipitation to investigate the role of Hsp90 in the PI3K/SGK-1 pathway.
Fri Jul 04 00:00:00 EDT 2008
Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1.
The Journal of biological chemistry
Belova L,Brickley DR,Ky B,Sharma SK,Conzen SD
MA3-011 was used in immunoprecipitation to investigate the role of Hsp90 in the PI3K/SGK-1 pathway.
Fri Jul 04 00:00:00 EDT 2008
The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor.
Molecular endocrinology (Baltimore, Md.)
Yoshikawa N,Yamamoto K,Shimizu N,Yamada S,Morimoto C,Tanaka H
MA3-011 was used in immunoprecipitation to study the mechanism for differential actions of various synthetic steroids on glucocorticoid receptor.
Sun May 01 00:00:00 EDT 2005
Aggresome formation.
Methods in molecular biology (Clifton, N.J.)
Corboy MJ,Thomas PJ,Wigley WC
MA3-011 was used in Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot to conclude that the centrosome may play a central role in protein quality control, sitting at the crossroads of protein folding, degradation, and aggregation.
Thu Jun 16 00:00:00 EDT 2005
Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation.
Brain research. Molecular brain research
Galigniana MD,Harrell JM,Housley PR,Patterson C,Fisher SK,Pratt WB
MA3-011 was used in immunocytochemistry to study the role of Hsp90 and CHIP in the retrograde transport of the glucocorticoid receptor in neurites
Wed Apr 07 00:00:00 EDT 2004
Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.
The Journal of biological chemistry
Squires EJ,Sueyoshi T,Negishi M
MA3-011 was used in immunoprecipitation to investigate the effect of cytoplasmic constitutive active/androstane receptor retention protein (CCRP) on pregnane X receptor localization.
Fri Nov 19 00:00:00 EST 2004
All of the protein interactions that link steroid receptor.hsp90.immunophilin heterocomplexes to cytoplasmic dynein are common to plant and animal cells.
Biochemistry
Harrell JM,Kurek I,Breiman A,Radanyi C,Renoir JM,Pratt WB,Galigniana MD
MA3-011 was used in ELISA to study the commonality of steroid-receptor-HSP90-immunophilin heterocomplex interactions with cytoplasmic dynein in plant and animal cells
Tue Apr 30 00:00:00 EDT 2002
Modification of an essential amino group in the mineralocorticoid receptor evidences a differential conformational change of the receptor protein upon binding of antagonists, natural agonists and the synthetic agonist 11,19-oxidoprogesterone.
Biochimica et biophysica acta
Piwien-Pilipuk G,Kanelakis KC,Ghini AA,Lantos CP,Litwack G,Burton G,Galigniana MD
MA3-011 was used in immunoprecipitation to study the role of an essential lysine residue in determining the hormone specificity of the mineralcorticoid receptor
Wed Feb 13 00:00:00 EST 2002
CFTR degradation and aggregation.
Methods in molecular medicine
Corboy MJ,Thomas PJ,Wigley WC
MA3-011 was used in Immunocytochemistry-immunofluorescence to discuss CFTR degradation and aggregation.
Thu Sep 05 00:00:00 EDT 2002
Host cell factor requirement for hepatitis C virus enzyme maturation.
Proceedings of the National Academy of Sciences of the United States of America
Waxman L,Whitney M,Pollok BA,Kuo LC,Darke PL
MA3-011 was used in Immunoprecipitation to identify HSP90 as an essential factor for the activity of the NS2/3 protease of hepatitis C virus.
Tue Nov 20 00:00:00 EST 2001
The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor.
Molecular and cellular biology
Kazlauskas A,Sundström S,Poellinger L,Pongratz I
MA3-011 was used in immunoprecipitation to investigate the role of the hsp90 molecular chaperone complex in the intracellular localization of the dioxin receptor.
Sun Apr 01 00:00:00 EST 2001
Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate.
The Journal of biological chemistry
Murphy PJ,Kanelakis KC,Galigniana MD,Morishima Y,Pratt WB
MA3-011 was used in western blot to demonstrate that the two chaperone proteins cooperate with each other to open up the steroid binding site.
Fri Aug 10 00:00:00 EDT 2001
In vitro reconstitution of a functional duck hepatitis B virus reverse transcriptase: posttranslational activation by Hsp90.
Journal of virology
Hu J,Anselmo D
MA3-011 was used in immunoprecipitation to investigate the role of Hsp90 during the activation of the reverse transcriptase.
Fri Dec 01 00:00:00 EST 2000
The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor.
The Journal of biological chemistry
Kazlauskas A,Poellinger L,Pongratz I
MA3-011 was used in immunoprecipitation to study the effect of XAP2 on dioxin receptor ubiquitination and subcellular localization.
Fri Dec 29 00:00:00 EST 2000
KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.
Cancer research
Soga S,Neckers LM,Schulte TW,Shiotsu Y,Akasaka K,Narumi H,Agatsuma T,Ikuina Y,Murakata C,Tamaoki T,Akinaga S
MA3-011 was used in western blot to investigate the mechanism of KF25706 for its in vivo antitumor activity
Tue Jun 15 00:00:00 EDT 1999
Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96.
Journal of immunology (Baltimore, Md. : 1950)
Ishii T,Udono H,Yamano T,Ohta H,Uenaka A,Ono T,Hizuta A,Tanaka N,Srivastava PK,Nakayama E
MA3-011 was used in western blot to determine the association of heat shock proteins with MHC class I-restricted tumor antigen precursors
Mon Feb 01 00:00:00 EST 1999
The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action.
The Journal of biological chemistry
Oakley RH,Jewell CM,Yudt MR,Bofetiado DM,Cidlowski JA
MA3-011 was used in immunoprecipitation to demonstrate mechanism of dominant negative activity of the human glucocorticoid receptor beta isoform
Fri Sep 24 00:00:00 EDT 1999
Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90, and cytoplasmic dynein.
The Journal of biological chemistry
Silverstein AM,Galigniana MD,Kanelakis KC,Radanyi C,Renoir JM,Pratt WB
MA3-011 was used in western blot to study the binding site for the association between the FKBP52/dimer and hsp90
Fri Dec 24 00:00:00 EST 1999
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin.
Cancer chemotherapy and pharmacology
Schulte TW,Neckers LM
MA3-011 was used in western blot to investigate the effect of 17-allylamino-17-demethoxygeldanamycin on heat shock protein 90 chaperone function
Thu Oct 08 00:00:00 EDT 1998
Active participation of Hsp90 in the biogenesis of the trimeric reovirus cell attachment protein sigma1.
The Journal of biological chemistry
Gilmore R,Coffey MC,Lee PW
MA3-011 was used in immunoprecipitation to demonstrate that chaperones play an important role in the regulation of general protein folding and of steroid receptor activation
Fri Jun 12 00:00:00 EDT 1998
Binding of hsp90 to the glucocorticoid receptor requires a specific 7-amino acid sequence at the amino terminus of the hormone-binding domain.
The Journal of biological chemistry
Xu M,Dittmar KD,Giannoukos G,Pratt WB,Simons SS
MA3-011 was used in ELISA to study the binding menchanism of hsp90 to the glucocorticoid receptor
Fri May 29 00:00:00 EDT 1998
Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor.
Proceedings of the National Academy of Sciences of the United States of America
Kallio PJ,Pongratz I,Gradin K,McGuire J,Poellinger L
MA3-011 was used in immunoprecipitation to study the hypoxia-inducible factor 1 alpha expression under hypoxia.
Tue May 27 00:00:00 EDT 1997
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced activation of a protein tyrosine kinase, pp60src, in murine hepatic cytosol using a cell-free system.
Molecular pharmacology
Blankenship A,Matsumura F
MA3-011 was used in immunoprecipitation to study pp60src activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
Wed Oct 01 00:00:00 EDT 1997
Disruption of the glucocorticoid receptor assembly with heat shock protein 90 by a peptidic antiglucocorticoid.
Molecular endocrinology (Baltimore, Md.)
Dao-Phan HP,Formstecher P,Lefebvre P
MA3-011 was used in immunoprecipitation to evaluate the effect of peptidic antiglucocorticoid on the interaction between glucocorticoid receptor and heat shock protein 90
Sun Jun 01 00:00:00 EDT 1997
Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin.
The Journal of biological chemistry
Silverstein AM,Galigniana MD,Chen MS,Owens-Grillo JK,Chinkers M,Pratt WB
MA3-011 was used in immunoprecipitation to identify PP5 as an important component of glucocorticoid receptor-hsp90 complexes and investigate its functional properties
Fri Jun 27 00:00:00 EDT 1997
Evidence that the beta-isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor.
The Journal of biological chemistry
Hecht K,Carlstedt-Duke J,Stierna P,Gustafsson J,Brönnegârd M,Wikström AC
MA3-011 was used in immunoprecipitation to study the role of the beta-isoform of human glucocorticoid receptor
Fri Oct 17 00:00:00 EDT 1997
Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation.
The Journal of biological chemistry
Dittmar KD,Pratt WB
MA3-011 was used in immunoprecipitation to study the folding of hormone binding domain of glucocorticoid receptor in vitro using reconstituted receptor-hsp90 heterocomplex assembly system with purified components
Fri May 16 00:00:00 EDT 1997
Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.
Proceedings of the National Academy of Sciences of the United States of America
Hu J,Seeger C
MA3-011 was used in blocking/activating experiment to investigate the role of Hsp90 on the activity of a hepatitis B virus reverse transcriptase
Tue Feb 06 00:00:00 EST 1996
Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.
Proceedings of the National Academy of Sciences of the United States of America
Blagosklonny MV,Toretsky J,Bohen S,Neckers L
MA3-011 was used in western blot to investigate the role of HSP90 in the proper folding of mutated p53
Tue Aug 06 00:00:00 EDT 1996
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.
Molecular and cellular biology
Gradin K,McGuire J,Wenger RH,Kvietikova I,fhitelaw ML,Toftgård R,Tora L,Gassmann M,Poellinger L
MA3-011 was used in immunoprecipitation to show HIF-1a is associated with the molecular chaperone hsp90 in vitro
Tue Oct 01 00:00:00 EDT 1996
The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant.
The Journal of biological chemistry
Chen MS,Silverstein AM,Pratt WB,Chinkers M
MA3-011 was used in western blot to investigate the role of tetratricopeptide repeat (TPR) domain of protein phosphatase 5 (PP5) in GR signaling
Fri Dec 13 00:00:00 EST 1996
A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains.
The Journal of biological chemistry
Owens-Grillo JK,Czar MJ,Hutchison KA,Hoffmann K,Perdew GH,Pratt WB
MA3-011 was used in immunoprecipitation to study the mechanisms of immunophilin-mediated protein targeting
Fri Jun 07 00:00:00 EDT 1996
The basic helix-loop-helix/PAS factor Sim is associated with hsp90. Implications for regulation by interaction with partner factors.
The Journal of biological chemistry
McGuire J,Coumailleau P,Whitelaw ML,Gustafsson JA,Poellinger L
MA3-011 was used in immunoprecipitation to study the interaction between Sim and hsp90
Fri Dec 29 00:00:00 EST 1995
Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity.
The Journal of biological chemistry
Coumailleau P,Poellinger L,Gustafsson JA,Whitelaw ML
MA3-011 was used in immunoprecipitation to detect the interaction between the dioxin receptor and Hsp90
Fri Oct 20 00:00:00 EDT 1995
Identification of functional domains of the aryl hydrocarbon receptor.
The Journal of biological chemistry
Fukunaga BN,Probst MR,Reisz-Porszasz S,Hankinson O
MA3-011 was used in immunoprecipitation to investigate the functional domains of mouse aryl hydrocarbon receptor
Fri Dec 08 00:00:00 EST 1995
Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.
Journal of immunology (Baltimore, Md. : 1950)
Udono H,Srivastava PK
MA3-011 was used in western blot to study the immunogenicity of gp96, hsp90 and hsp70 derived from Met A sarcoma
Wed Jun 01 00:00:00 EDT 1994
Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation.
Molecular and cellular biology
Whitelaw ML,Gustafsson JA,Poellinger L
MA3-011 was used in immunoprecipitation to study the mechanisms for transcriptional activation by dioxin receptor and Arnt
Thu Dec 01 00:00:00 EST 1994
A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor.
Molecular and cellular biology
McGuire J,Whitelaw ML,Pongratz I,Gustafsson JA,Poellinger L
MA3-011 was used in immunoprecipitation to investigate the role of Arnt for release of hsp90 from the dioxin receptor in the presence of dioxin
Fri Apr 01 00:00:00 EST 1994
A tyrosine kinase-dependent pathway regulates ligand-dependent activation of the dioxin receptor in human keratinocytes.
The Journal of biological chemistry
Gradin K,Whitelaw ML,Toftgård R,Poellinger L,Berghard A
MA3-011 was used in immunoprecipitation to investigate the role of a tyrosine kinase-dependent pathway during ligand-dependent activation of the dioxin receptor in human keratinocytes
Fri Sep 23 00:00:00 EDT 1994
Characterization of the protein-protein interactions determining the heat shock protein (hsp90.hsp70.hsp56) heterocomplex.
The Journal of biological chemistry
Czar MJ,Owens-Grillo JK,Dittmar KD,Hutchison KA,Zacharek AM,Leach KL,Deibel MR,Pratt WB
MA3-011 was used in immunoprecipitation to investigate the interaction of different protein components of the heat shock protein heterocomplex
Fri Apr 15 00:00:00 EDT 1994
ATP-dependent protein refolding activity in reticulocyte lysate. Evidence for the participation of different chaperone components.
FEBS letters
Nimmesgern E,Hartl FU
MA3-011 was used in western blot to investigate the role of chaperone components for energy-dependent protein refolding activity
Mon Sep 27 00:00:00 EDT 1993