This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human IL-1R8/IL1RAPL1.
The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signaling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; IL1RAPL1; interleukin 1 receptor accessory protein-like 1; interleukin 1 receptor-8; Interleukin-1 receptor accessory protein-like 1; mental retardation, X-linked 10; Oligophrenin-4; OPHN4; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1
Gene Aliases: IL1R8; IL1RAPL; IL1RAPL1; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2
UniProt ID: (Human) Q9NZN1
Entrez Gene ID: (Human) 11141