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Product Details
TA505700
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4D7
Immunogen
Full length human recombinant protein of human MAPK3 produced in HEK293T cell.
Conjugate
Unconjugated
Form
liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Target Information
ERK1 is widely expressed and involved in the regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1. Functionally, ERK1 is involved with a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. ERK1 is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms of ERK1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ERK; ERK-1; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 3; MAP kinase isoform p44; MAP kinase2; MAPK 1; MAPK2; Microtubule-associated protein 2 kinase; Mitogen-activated protein kinase 3; p44-ERK1; p44-MAPK
Gene Aliases: ERK-1; ERK1; ERT2; HS44KDAP; HUMKER1A; MAPK3; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3
UniProt ID: (Human) P27361
Entrez Gene ID: (Human) 5595, (Dog) 100855877
Molecular Function:
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPK activity
MAPK import into nucleus
positive regulation of protein phosphorylation
transcription initiation from RNA polymerase I promoter
protein complex assembly
protein phosphorylation
apoptotic process
DNA damage induced protein phosphorylation
cell cycle
axon guidance
fibroblast growth factor receptor signaling pathway
response to toxic substance
regulation of phosphatidylinositol 3-kinase signaling
viral process
phosphorylation
peptidyl-serine phosphorylation
sensory perception of pain
arachidonic acid metabolic process
platelet activation
BMP signaling pathway
thyroid gland development
positive regulation of cyclase activity
lipopolysaccharide-mediated signaling pathway
positive regulation of telomere maintenance via telomerase
regulation of stress-activated MAPK cascade
positive regulation of histone phosphorylation
positive regulation of histone acetylation
peptidyl-tyrosine autophosphorylation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
outer ear morphogenesis
response to exogenous dsRNA
positive regulation of translation
positive regulation of transcription from RNA polymerase II promoter
thymus development
regulation of sequence-specific DNA binding transcription factor activity
cartilage development
regulation of cytoskeleton organization
positive regulation of telomerase activity
Bergmann glial cell differentiation
face development
JAK-STAT cascade involved in growth hormone signaling pathway
lung morphogenesis
trachea formation
cardiac neural crest cell development involved in heart development
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
interleukin-1-mediated signaling pathway
response to epidermal growth factor
cellular response to mechanical stimulus
caveolin-mediated endocytosis
regulation of Golgi inheritance
regulation of cellular response to heat
positive regulation of telomere capping
positive regulation of xenophagy
regulation of early endosome to late endosome transport
negative regulation of apolipoprotein binding
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