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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human MAP2K2 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/200 - 1/400|
|Immunofluorescence (IF)||1/200 - 1/1000|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15600 targets MAP2K2 in FACS, IF, and WB applications and shows reactivity with Human, mouse, and Rat samples.
The MA5-15600 immunogen is purified recombinant fragment of human MAP2K2 expressed in E. Coli.
MA5-15600 detects MAP2K2 which has a predicted molecular weight of approximately 44kDa.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome , a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; FLJ26075; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP2K2; MAPK/ERK kinase 2; MAPKK 2; MAPKK2; MEK 2; MEK2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; PRKMK2; protein kinase, mitogen activated, kinase 2, p45
AA589381; CFC4; MAP2K2; MAPKK2; MEK2; MK2; MKK2; PRKMK2