This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with bovine, chicken, mouse and rat based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
MEK2 belongs to the family of mitogen-activated protein kinase kinases that phosphorylate threonine and tyrosine residues within the activation loop of their MAP kinase substrates. The ERK1/2 MAP kinase signaling pathway is an integral part of cell proliferation control and is frequently activated in human colorectal cancer. Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221 and is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAPK/ERK kinase 2; MAPKK 2; MEK2; mitogen-activated protein kinase kinase 2, p45
Gene Aliases: CFC4; MAPKK2; MEK2; MKK2; PRKMK2
Entrez Gene ID: (Human) 5605