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For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
MettL7A belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: methyltransferase like 7A-like; Methyltransferase-like protein 7A; N6-adenosine-methyltransferase TMT1A; Protein AAM-B; Thiol methyltransferase 1A; Thiol S-methyltransferase TMT1A
Gene Aliases: AAM-B; METTL7A; PRO0066; RGD1308407; TMT1A; UNQ1902/PRO4348
UniProt ID: (Human) Q9H8H3
Entrez Gene ID: (Human) 25840, (Rat) 315306
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