This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
MA5-17123 targets MMP3 in FACS, pep-ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17123 immunogen is purified recombinant fragment of human MMP3 expressed in E. Coli.
MA5-17123 detects MMP3 which has a predicted molecular weight of approximately 54kDa.
MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted in its pro-protein form, and is activated by extracellular proteinase cleavage. MMP3 is capable of binding to zinc and calcium ions, and has metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin. It is involved in normal cellular processes such as wound repair and tissue remodeling. Mutations in the gene can result in coronary heart disease 6.
Protein Aliases: EC 220.127.116.11; EMS-2; matrix metallo protease; matrix metalloproteinase 3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Matrix metalloproteinase-3; MMP; MMP-3; MMPs; progelatinase; proteoglycanase; SL-1; stromelysin 1; Stromelysin-1; Stromelysin1; Transin-1; Transin1
Gene Aliases: CHDS6; MMP-3; MMP3; SL-1; SLN-1; SLN1; STMY; STMY1; STR-1; STR1