MA5-15917 targets MSH6 in WB applications and shows reactivity with Human samples.
The MA5-15917 immunogen is purified recombinant fragment of human MSH6 expressed in E. Coli. .
MA5-15917 detects MSH6 which has a predicted molecular weight of approximately 160kDa.
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.
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Protein Aliases: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTBP, HNPCC5, HSAP, DNA mismatch repair protein Msh6; GTMBP; hMSH6; MutS protein homolog 6; MutS-alpha 160 kDa subunit; p160; sperm-associated protein
Gene Aliases: GTBP; GTMBP; HNPCC5; HSAP; MSH6; p160
UniProt ID: (Human) P52701
Entrez Gene ID: (Human) 2956