Invitrogen

MSH6 Monoclonal Antibody (5B11)

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MSH6 Antibody in Western Blot (WB) — Western blot analysis of MSH6 using a MSH6 monoclonal antibody (Product # MA5-15917) against a human MSH6 (AA: 217-395) recombinant protein.

Product Details

Tested Applications

Dilution

Western Blot (WB)

1/500 - 1/2000

Product Specifications

Species Reactivity

Human

Host / Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5B11

Immunogen

Purified recombinant fragment of human MSH6 expressed in E. Coli.

Conjugate

Unconjugated

Form

Liquid

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_11154784

Product Specific Information

MA5-15917 targets MSH6 in WB applications and shows reactivity with Human samples.

The MA5-15917 immunogen is purified recombinant fragment of human MSH6 expressed in E. Coli. .

MA5-15917 detects MSH6 which has a predicted molecular weight of approximately 160kDa.

Target Information

This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: DNA mismatch repair protein Msh6; G/T mismatch-binding protein; GTBP; GTBP, HNPCC5, HSAP, DNA mismatch repair protein Msh6; GTMBP; hMSH6; MutS protein homolog 6; MutS-alpha 160 kDa subunit; p160; sperm-associated protein

Gene Aliases: GTBP; GTMBP; HNPCC5; HSAP; MSH6; p160

UniProt ID: (Human) P52701

Entrez Gene ID: (Human) 2956

Molecular Function: DNA binding protein nucleic acid binding