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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues A(372) E D E E E E G T M K R R D E T M Q P(390) of human MST-1.|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody will cross-react with mouse and rat MST-1, based on sequence homology.
Suggested positive control: Jurkat whole cell lysate.
Mammalian STE20-like kinase 1, or MST-1, is a serine/threonine kinase that, upon cleavage, has been implicated in the promotion of chromatin condensation. MST-1 is also known as KRS2 and STK4. The C-terminus of MST-1 contains two functional NESs (nuclear export signals), which are released upon caspase-mediated cleavage. The N-terminus portion of the protein then translocates to the nucleus and will promote chromatin condensation at sufficiently high levels. Full-length MST-1 is localized to the cytoplasm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
kinase responsive to stress 2; KRS2; mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; serine/threonine-protein kinase Krs-2; STE20-like kinase MST1; STK4
KRS2; MST1; STK4; YSK3