This antibody is predicted to react with rat based on sequence homology.
Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders.
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Protein Aliases: Exophilin-3; leaden; Leaden protein; Melanophilin; MGC2771; MGC59733; OTTMUSP00000025451; SlaC2-a; Slp homolog lacking C2 domains a; Synaptotagmin-like protein 2a
Gene Aliases: 2210418F23Rik; 5031433I09Rik; AW228792; D1Wsu84e; l(1)-3Rk; l1Rk3; Ln; Mlph; Slac-2a; Slac2a
UniProt ID: (Mouse) Q91V27
Entrez Gene ID: (Mouse) 171531
Molecular Function: myelin protein