Product References
MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61.
Oncogene
Zarei M,Giannikou K,Du H,Liu HJ,Duarte M,Johnson S,Nassar AH,Widlund HR,Henske EP,Long HW,Kwiatkowski DJ
MA5-14154 was used in Western Blotting to show that MITF-A is a transcriptional oncogenic driver of angiomyolipoma tumor development, acting through regulation of CYR61.
Fri Jan 01 00:00:00 EST 2021
MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61.
Oncogene
Zarei M,Giannikou K,Du H,Liu HJ,Duarte M,Johnson S,Nassar AH,Widlund HR,Henske EP,Long HW,Kwiatkowski DJ
MA5-14154 was used in Western Blotting to show that MITF-A is a transcriptional oncogenic driver of angiomyolipoma tumor development, acting through regulation of CYR61.
Fri Jan 01 00:00:00 EST 2021
Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.
Cancer cell
Hanniford D,Ulloa-Morales A,Karz A,Berzoti-Coelho MG,Moubarak RS,Sánchez-Sendra B,Kloetgen A,Davalos V,Imig J,Wu P,Vasudevaraja V,Argibay D,Lilja K,Tabaglio T,Monteagudo C,Guccione E,Tsirigos A,Osman I,Aifantis I,Hernando E
MA5-14154 was used in Western Blotting to identify silencing of cerebellar degeneration-related 1 antisense (CDR1as), a regulator of miR-7, as a hallmark of melanoma progression.
Mon Jan 13 00:00:00 EST 2020
Directing Differentiation of Pluripotent Stem Cells Toward Retinal Pigment Epithelium Lineage.
Stem cells translational medicine
Choudhary P,Booth H,Gutteridge A,Surmacz B,Louca I,Steer J,Kerby J,Whiting PJ
MA514154 was used in immunocytochemistry to propose a method for deriving homogeneous retinal pigment epithelium populations using an adherent, monolayer system and defined xeno-free media and matrices
Wed Feb 01 00:00:00 EST 2017
Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.
Molecular systems biology
Fallahi-Sichani M,Becker V,Izar B,Baker GJ,Lin JR,Boswell SA,Shah P,Rotem A,Garraway LA,Sorger PK
MA514154 was used in immunohistochemistry - paraffin section to find that exposure of tumor cells to RAF/MEK inhibitors elicits a heterogeneous response in which some cells die, some arrest, and the remainder adapt to drug
Mon Jan 09 00:00:00 EST 2017
Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state.
Molecular systems biology
Fallahi-Sichani M,Becker V,Izar B,Baker GJ,Lin JR,Boswell SA,Shah P,Rotem A,Garraway LA,Sorger PK
MA514154 was used in immunohistochemistry - paraffin section to find that exposure of tumor cells to RAF/MEK inhibitors elicits a heterogeneous response in which some cells die, some arrest, and the remainder adapt to drug
Mon Jan 09 00:00:00 EST 2017
Unusual clear cell, lymphoplasmacyte-rich, dural-based tumor with divergent differentiation: a tricky case mimicking a meningioma.
Human pathology
Miracco C,Toscano M,Butorano MA,Baldino G,Tacchini D,Barone A,Cerase A
MA5-14154 was used in immunohistochemistry - paraffin section to describe an unusual case of a recurrent dural neoplasm
Wed Jul 01 00:00:00 EDT 2015
Melanocytic differentiation is present in a significant proportion of nonpigmented diffuse neurofibromas: a potential diagnostic pitfall.
The American journal of surgical pathology
Pižem J,Nicholson KM,Mraz J,Prieto VG
MA5-14154 was used in immunohistochemistry to study the occurrence of melanocytic differentiation in non-pigmented diffuse neurofibromas and the diagnostic implications
Thu Aug 01 00:00:00 EDT 2013
Secondary c-Kit mutations confer acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells.
Pigment cell & melanoma research
Todd JR,Becker TM,Kefford RF,Rizos H
MA5-14154 was used in western blot to study the acquisition of resistance to RTK inhibitors by c-Kit mutant melanoma cells through secondary c-Kit mutations and the therapeutic implications
Mon Jul 01 00:00:00 EDT 2013
PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).
PloS one
Nicholas C,Yang J,Peters SB,Bill MA,Baiocchi RA,Yan F,Sïf S,Tae S,Gaudio E,Wu X,Grever MR,Young GS,Lesinski GB
MA5-14154 was used in western blot to study the increased immunohistochemical expression of PRMT5 in malignant and metastatic melanoma and the pathological significance
Mon May 12 00:00:00 EDT 2014
Cathepsin K expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Martignoni G,Bonetti F,Chilosi M,Brunelli M,Segala D,Amin MB,Argani P,Eble JN,Gobbo S,Pea M
MA5-14154 was used in immunohistochemistry to investigate the expression of cathepsin K in kidney perivascular epithelioid cell lesions
Sun Jan 01 00:00:00 EST 2012
Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor.
Pigment cell & melanoma research
Boyle GM,Woods SL,Bonazzi VF,Stark MS,Hacker E,Aoude LG,Dutton-Regester K,Cook AL,Sturm RA,Hayward NK
MA5-14154 was used in western blot to investigate the mechanism for the regulation of melanoma invasiveness
Wed Jun 01 00:00:00 EDT 2011
Bilateral renal tumors; conventional clear cell carcinoma and contralateral t(6;11)/t(X;17)-like tumor Histomorphologic, immunohistochemical, ultrastructural and molecular genetic studies including the report of a novel mutation in the VHL gene.
Annals of diagnostic pathology
Petersson F,Michal M,Vaněček T,Hora M,Trivunic S,Halbhuber Z,Hes O
MA5-14154 was used in immunohistochemistry to report on a pregnant woman with bilateral renal tumors
Sat Oct 01 00:00:00 EDT 2011
MART-1 is a reliable melanocytic marker in lichen planus-like keratosis: a study on 70 cases.
The American Journal of dermatopathology
Gavino AC,Woods MT,Andea AA
MA5-14154 was used in immunohistochemistry to evaluate the suitability of MART-1 as a marker for melanocytic nests in lichen planus-like keratosis
Sat Oct 01 00:00:00 EDT 2011
PAX3 and SOX10 activate MET receptor expression in melanoma.
Pigment cell & melanoma research
Mascarenhas JB,Littlejohn EL,Wolsky RJ,Young KP,Nelson M,Salgia R,Lang D
MA5-14154 was used in immunohistochemistry to investigate the role of SOX3,SOX10,MITF and MET in human melanoma tumorigenesis
Thu Apr 01 00:00:00 EDT 2010
MicroRNA-25 functions in regulation of pigmentation by targeting the transcription factor MITF in Alpaca (Lama pacos) skin melanocytes.
Domestic animal endocrinology
Zhu Z,He J,Jia X,Jiang J,Bai R,Yu X,Lv L,Fan R,He X,Geng J,You R,Dong Y,Qiao D,Lee KB,Smith GW,Dong C
MA5-14154 was used in western blot to study the mechanism by which microRNA-25 regulates pigmentation in Alpaca skin melanocytes
Thu Apr 01 00:00:00 EDT 2010
Cathepsin-k expression in pulmonary lymphangioleiomyomatosis.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Chilosi M,Pea M,Martignoni G,Brunelli M,Gobbo S,Poletti V,Bonetti F
MA5-14154 was used in immunohistochemistry to examine the role of cathepsin-k in the pathogenesis of pulmonary lymphangioleiomyomatosis
Sun Feb 01 00:00:00 EST 2009
Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Martignoni G,Pea M,Gobbo S,Brunelli M,Bonetti F,Segala D,Pan CC,Netto G,Doglioni C,Hes O,Argani P,Chilosi M
MA5-14154 was used in immunohistochemistry to examine the diagnostic significance of cathepsin-K immunoreactivity in MiTF/TFE family renal translocation carcinomas
Sat Aug 01 00:00:00 EDT 2009
Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity.
The Journal of investigative dermatology
Boyle GM,Pedley J,Martyn AC,Banducci KJ,Strutton GM,Brown DA,Breit SN,Parsons PG
MA5-14154 was used in western blot to study the role of macrophage inhibitory cytokine-1 overexpression in malignant melanoma
Sun Feb 01 00:00:00 EST 2009
Metastatic desmoplastic malignant melanoma associated with low-grade myofibroblastic sarcoma.
The American Journal of dermatopathology
Kacerovska D,Michal M,Kutzner H,Rychnovsky J,Kazakov DV
MA5-14154 was used in immunohistochemistry to report on a case of metastatic desmoplastic malignant melanoma associated with low-grade myofibroblastic sarcoma
Wed Jul 01 00:00:00 EDT 2009
Low-grade sarcoma in classical seminoma - the first case reported.
International journal of clinical and experimental pathology
Petersson F,Michal M,Grossmann P,Franco M,Zámecník M,Hes O
MA5-14154 was used in immunohistochemistry to report on a case of low-grade sarcoma in classical seminoma
Sun Nov 01 00:00:00 EDT 2009
MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines.
Cancer research
Bemis LT,Chen R,Amato CM,Classen EH,Robinson SE,Coffey DG,Erickson PF,Shellman YG,Robinson WA
MA5-14154 was used in western blot to confirm the role of miR-137 in the regulation of microphthalmia-associated transcription factor expression
Sat Mar 01 00:00:00 EST 2008
Melanocytes expressing MC1R polymorphisms associated with red hair color have altered MSH-ligand activated pigmentary responses in coculture with keratinocytes.
Journal of cellular physiology
Roberts DW,Newton RA,Leonard JH,Sturm RA
MA5-14154 was used in western blot to study the behavior and functional abilities of melanocytes expressing MC1R red hair color variants
Thu May 01 00:00:00 EDT 2008
Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases.
The American journal of surgical pathology
Hisaoka M,Ishida T,Kuo TT,Matsuyama A,Imamura T,Nishida K,Kuroda H,Inayama Y,Oshiro H,Kobayashi H,Nakajima T,Fukuda T,Ae K,Hashimoto H
MA5-14154 was used in immunohistochemistry to analyse 33 clinical cases of clear cell sarcoma of soft tissue
Sat Mar 01 00:00:00 EST 2008
Biphasic malignant mesothelioma cases with osseous differentiation and long survival: a review of the literature.
Lung cancer (Amsterdam, Netherlands)
Demirag F,Unsal E,Tastepe I
MA5-14154 was used in immunohistochemistry to report two clinical cases of biphasic malignant mesothelioma with osseous differentiation
Wed Aug 01 00:00:00 EDT 2007
VMD2 promoter requires two proximal E-box sites for its activity in vivo and is regulated by the MITF-TFE family.
The Journal of biological chemistry
Esumi N,Kachi S,Campochiaro PA,Zack DJ
MA5-14154 was used in EMSA to study the role of E-box sites and microphthalmia-associated transcription factors in the in vivo activity of the VMD2 promoter
Fri Jan 19 00:00:00 EST 2007
Distinct phenotypic changes between the superficial and deep component of giant congenital melanocytic naevi: a rationale for curettage.
The British journal of dermatology
De Raeve LE,Claes A,Ruiter DJ,van Muijen GN,Roseeuw D,van Kempen LC
MA5-14154 was used in immunohistochemistry to study the phenotypic changes between the superficial and deep component of giant congenital melanocytic naevi
Wed Mar 01 00:00:00 EST 2006
Mechanisms of skin tanning in different racial/ethnic groups in response to ultraviolet radiation.
The Journal of investigative dermatology
Tadokoro T,Yamaguchi Y,Batzer J,Coelho SG,Zmudzka BZ,Miller SA,Wolber R,Beer JZ,Hearing VJ
MA5-14154 was used in immunohistochemistry to study the mechanisms by which UV radiation stimulates skin pigmentation in different ethnic groups
Wed Jun 01 00:00:00 EDT 2005
Immunohistochemical analysis of novel monoclonal antibody PNL2 and comparison with other melanocyte differentiation markers.
The American journal of surgical pathology
Busam KJ,Kucukgöl D,Sato E,Frosina D,Teruya-Feldstein J,Jungbluth AA
MA5-14154 was used in immunohistochemistry to investigate the usefulness of a novel antibody PNL2 for melanocyte staining
Tue Mar 01 00:00:00 EST 2005
Paraganglioma-like dermal melanocytic tumor: a unique entity distinct from cellular blue nevus, clear cell sarcoma, and cutaneous melanoma.
The American journal of surgical pathology
Deyrup AT,Althof P,Zhou M,Morgan M,Solomon AR,Bridge JA,Weiss SW
MA5-14154 was used in immunohistochemistry to report on a study of paraganglioma-like dermal melanocytic tumor in 8 patients
Wed Dec 01 00:00:00 EST 2004
Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas.
The American journal of surgical pathology
Xu X,Chu AY,Pasha TL,Elder DE,Zhang PJ
MA5-14154 was used in immunohistochemistry to investigate the expression of protein markers associated with melanoma and melanocytic differentiation in HMB45-negative melanomas
Tue Jan 01 00:00:00 EST 2002
Congenital giant melanocytic nevus with pigmented epithelioid cells: a variant of epithelioid blue nevus.
The American Journal of dermatopathology
Martínez-Barba E,Polo-García LA,Ferri-Níguez B,Ruiz-Maciá JA,Kutzner H,Requena L
MA5-14154 was used in immunohistochemistry to report a case study of a boy with a giant melanocytic variant of epithelioid blue nevus.
Fri Feb 01 00:00:00 EST 2002
Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa.
The American journal of surgical pathology
Prasad ML,Jungbluth AA,Iversen K,Huvos AG,Busam KJ
MA5-14154 was used in immunohistochemistry to study the expression of melanocytic differentiation markers in oral and sinonasal melanomas
Fri Jun 01 00:00:00 EDT 2001
Microphthalmia transcription factor in the immunohistochemical diagnosis of metastatic melanoma: comparison with four other melanoma markers.
The American journal of surgical pathology
Miettinen M,Fernandez M,Franssila K,Gatalica Z,Lasota J,Sarlomo-Rikala M
MA5-14154 was used in immunohistochemistry to study microphthalmia transcription factor as a diagnostic marker of metastatic melanoma.
Thu Feb 01 00:00:00 EST 2001