Suggested positive control: antigen standard for MYC (transient overexpression lysate), HL-60 cells or breast tumors, HL-60 whole cell lysate, human breast carcinoma whole cell lysate.
The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; c-Myc; c-myc proto-oncogene; Cellular myelocytomatosis oncogene; Class E basic helix-loop-helix protein 39; Myc proto oncogene protein; Myc proto-oncogene protein; myc-related translation/localization regulatory factor; Myc2; Niard; Nird; Proto-oncogene c-Myc; Transcription factor p64; v myc avian myelocytomatosis viral oncogene hom; v-myc myelocytomatosis viral oncogene homolog
Gene Aliases: AU016757; BHLHE39; c-Myc; MRTL; MYC; Myc2; MYCC; Niard; Nird