|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide: D(532) T N S L Q N G D K L Q K R P E K R Q(550)|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4398 detects NABC1 in human samples.
PA1-4398 has been successfully used in Western blotting procedures. By Western blot, this antibody detects a ~60 kDa protein representing NABC1 in MCF-7 cell lysates. NABC1 can form dimers, which are readily detectable in MCF-7 cells.
PA1-4398 immunizing peptide corresponds to amino acid residues 532-550 of human NABC1.
A novel gene, Novel Amplified in Breast Cancer-1 (NABC1) is implicated in breast cancer development. Breast tumor lines that harbor amplification of the cancer-related amplicon 2-q13.2 display high levels of the NABC1 protein compared to normal human fibroblasts or a breast cancer line that does not overexpress the NABC1 mRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.