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Proteintech
NFIX Monoclonal Antibody (1E8A1)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
67983-1-IG150UL
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1E8A1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCAAT-box-binding transcription factor; DNA-binding, transcription factor; KIAA1439; NF-I/A; NF-I/B; NF-I/C; NF1-A; NF1-B; NF1-C; NF1-X1 protein; NFI; NFI-A; NFI-B; NFI-C; NFIA; NFIB; NFIC; nuclear factor 1 X; Nuclear factor 1/A; Nuclear factor 1/B; Nuclear factor 1/C; nuclear factor 1/X; Nuclear factor I/A; Nuclear factor I/B; Nuclear factor I/C; nuclear factor I/X (CCAAT-binding transcription factor); TGGCA-binding protein; transcription factor; unnamed protein product
Gene Aliases: CTF; MALNS; MRSHSS; NF-I/X; NF1-X; NF1A; Nf1x; NFI-X; SOTOS2
UniProt ID: (Human) Q14938, (Mouse) P70257
Entrez Gene ID: (Rabbit) 100350712, (Human) 4784, (Pig) 100523536, (Mouse) 18032, (Rat) 81524
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell morphogenesis
skeletal system development
tissue homeostasis
endochondral ossification
osteoclast proliferation
phagocytosis
inflammatory response
Rho protein signal transduction
neuroblast proliferation
brain development
skeletal muscle tissue development
learning
memory
response to wounding
exit from mitosis
gene expression
glial cell proliferation
neuroblast differentiation
skeletal muscle satellite cell differentiation
stem cell population maintenance
spinal cord development
cerebellum development
lateral ventricle development
cerebellar Purkinje cell layer development
cerebellar cortex morphogenesis
cerebellar granule cell differentiation
hippocampus development
olfactory bulb development
glial cell fate specification
glial cell development
cell proliferation in forebrain
forebrain radial glial cell differentiation
cerebral cortex development
neurogenesis
neuron differentiation
macrophage differentiation
bone mineralization
osteoclast differentiation
forebrain development
regeneration
social behavior
multicellular organism growth
gliogenesis
camera-type eye development
skeletal muscle tissue regeneration
negative regulation of neuron apoptotic process
ear development
cell maturation
neuron fate specification
collateral sprouting
generation of neurons
astrocyte differentiation
oligodendrocyte differentiation
brain morphogenesis
homeostasis of number of cells within a tissue
retina development in camera-type eye
epithelium development
neural precursor cell proliferation
cellular response to BMP stimulus
neuroblast migration
atrioventricular canal morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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