Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Deaminated glutathione amidase; dGSH amidase; MGC57670; nitrilase 1; Nitrilase homolog 1
Gene Aliases: NIT1
UniProt ID: (Human) Q86X76
Entrez Gene ID: (Human) 4817
Molecular Function: hydrolase