|Tested species reactivity||Human, Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 173 and 510 of Human NMDAR2A|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
PA5-27921 targets NMDAR2A in IHC (P) and WB applications and shows reactivity with Human, Rat and mouse samples.
The PA5-27921 immunogen is recombinant fragment corresponding to a region within amino acids 173 and 510 of Human NMDAR2A.
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model.
PA5-27921 was used in immunohistochemistry to elucidate the role of metallothionein-1 in prostate cancer using a prostate-specific MT1-expressing mouse
|Tam NN,Zhang X,Xiao H,Song D,Levin L,Meller J,Ho SM||Laboratory investigation; a journal of technical methods and pathology (95:546)||2015|