This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated. View Details
NME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in the gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
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Protein Aliases: expressed in non-metastatic cells 1; expressed in non-metastatic cells 1 protein (NM23A) (nucleoside diphosphate kinase); expressed in non-metastatic cells 1, protein (NM23A) (nucleoside diphosphate kinase); GAAD; Granzyme A-activated DNase; Metastasis inhibition factor NM23; NDK A; NDP kinase A; NDP kinase beta; nm23-C1; NM23-H1; non-metastatic cells 1, protein (NM23A) expressed in; Nucleoside diphosphate kinase A; nucloside diphosphate kinase; Tumor metastatic process-associated protein
Gene Aliases: AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-C1; NM23-H1; NM23A; NME1
Molecular Function: kinase