Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; Diphosphoinositol polyphosphate phosphohydrolase 2; Diphosphoinositol polyphosphate phosphohydrolase NUDT4B; diphosphoinositol polyphosphate phosphohydrolase type 2; DIPP-2; DIPP-2B; DIPP2; DIPP2alpha; DIPP2beta; HDCMB47P; Nucleoside diphosphate-linked moiety X motif 4; Nucleoside diphosphate-linked moiety X motif 4B; nudix (nucleoside diphosphate linked moiety X)-type motif 4; Nudix hydrolase 4B; Nudix motif 4; Nudix motif 4B
Gene Aliases: DIPP2; DIPP2alpha; DIPP2beta; HDCMB47P; KIAA0487; NUDT4; NUDT4B
UniProt ID: (Human) Q9NZJ9
Entrez Gene ID: (Human) 11163