The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.
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Protein Aliases: C-terminal-flanking peptide; neurokinin 1; neurokinin 2; Neurokinin A; neurokinin alpha; Neuromedin L; Neuropeptide gamma; Neuropeptide K; NKA; NPK; PPT; preprotachykinin; protachykinin; Protachykinin-1; Substance K; Substance P; tachykinin 2; tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
Gene Aliases: Hs.2563; NK2; NKA; NKNA; NPK; TAC1; TAC2
UniProt ID: (Human) P20366
Entrez Gene ID: (Human) 6863