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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG3|
|Immunogen||White blood cells.|
|Contains||0.08% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||10 µl/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This monoclonal anti-CD15 antibody is an IgG3 fraction which will not agglutinate cells, as opposed to most other IgM antibodies which cause cells to aggregate in the cytometer.
Monoclonal Anti-Human CD15 antibody recognizes the CD15 antigen. The CD15 antigen is expressed on approximately 90% human circulating granulocytes (membranes and granules), 30-60% of circulating monocytes and is absent from normal lymphocytes. CD15 antigen is also expressed on Reed Sternberg cells of Hodgkin's disease, on T cell lymphomas including mycosis fungoides and on some leukemias. Outside the hematopoietic system, CD15 expression is described in certain normal and neoplastic epithelial cells and in astrocytes. CD15 antibodies recognize the tri-saccharide 3-fucosyllactosamine (3-Fl) which is present in lacto-N-fucopentaose III and in the blood group antigen X-hapten. At least 5 major CD15 antigens (105, 135, 165, 185, 220 kDa) are present on the surface membranes of polymorphonuclear cells. The hapten occurs also in glycolipids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
alpha (1,3) fucosyltransferase, myeloid-specific; CD15; ELAM ligand fucosyltransferase; ELAM-1 ligand fucosyltransferase; ELFT; FCT3A; FUC-TIV; fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); fucosyltransferase IV; fucT-IV; FUTIV; galactoside 3-L-fucosyltransferase; Lewis X; LeX; SSEA-1; stage-specific embryonic antigen 1
CD15; ELFT; FCT3A; FUC-TIV; FUT4; FUTIV; LeX; SSEA-1