Immunogen sequence: TKKILMGNEE LTRLWNLCPD NMEACKSETR EHMPTLEEFF EEAIEQADPE NMVENEYKAV NNSNYGWRAL RLLARRSPHF FQPTNQQFKS LPEYLENMVI KLAKELPPPS EEIKTGEDED EEDNDALLKE NESPDVRRDK PVTGEQIEVF ANKLGEQWKI LAPYLEMKDS EIRQIECDSE DMKMRAKQLL VAWQDQEGVH ATPENLINAL NKSGLSDLAE SLTNDNETNS; Positive Samples: BT-474, MCF7, A-549, HeLa, HepG2; Cellular Location: Cytoplasm, Cytoplasm, Nucleus, Nucleus matrix, Nucleus speckle, nucleoplasm
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
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Protein Aliases: hTREX84; Nuclear matrix protein p84; p84N5; THO complex subunit 1; Tho1
Gene Aliases: 3110002N20Rik; AW107452; HPR1; LRRGT00070; NMP-84; P84; P84N5; THOC1
Molecular Function: nucleic acid binding