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O-acetyl GD3 is a naturally occurring modification of GD3 (O-acetylation) that can reverse its apoptotic effects, suggesting a way for cells to avoid the fate of Gd3-induced apoptosis. Glycosphingolipids (GSLs) are amphipathic molecules with a polar glycan chain as a head group and a hydrophobic sphingosine-containing ceramide tail, which is typically embedded in the outer leaflet of the plasma membrane. A GSL called Gd3 has recently been shown to be involved in Fas-mediated apoptosis in hematopoietic cells, causing the loss of mitochondrial potential and the release of apoptotic factors.
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