OBFC1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
Protein Aliases: alpha accessory factor 44; CST complex subunit STN1; oligonucleotide/oligosaccharide-binding fold containing 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; replication protein A 32 kDa subunit; Suppressor of cdc thirteen homolog
Gene Aliases: AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32; STN1
UniProt ID: (Human) Q9H668
Entrez Gene ID: (Human) 79991