PA1-18416 detects Oxytocin from ovine samples. Other species have not yet been tested.
PA1-18416 has been successfully used in immunohistochemistry applications.
The PA1-18416 immunogen is a synthetic peptide (CYIQNCPLG) corresponding to the amino acids 20 - 28 from human Oxytocin-neurophysin 1, conjugated to carrier protein.
Reconstitute with 50 µL of distilled water.
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Neurophysin 1; Ocytocin; OT-NPI; Oxytocin; oxytocin, prepro- (neurophysin I); oxytocin, prepropeptide; Oxytocin-neurophysin 1; oxytocin-neurophysin I; prepropeptide for oxytocin and neurophysin; unnamed protein product
Gene Aliases: OT-NPI; OXT
UniProt ID: (Sheep) P13389
Entrez Gene ID: (Sheep) 443390