PA1-10882 detects SOX6 in human and mouse samples. This antibody is predicted to recognize rat and chimapanzee SOX6 based on 100% sequence homology.
PA1-10882 has been successfully used in Western blot procedures.
PA1-10882 immunogen is a synthetic peptide corresponding to residues 780-796 of human and mouse SOX6.
The SOX gene family is defined by the Sry-related HMG box domain that mediates sequence-specific DNA binding. A variety of functions are associated with the SOX proteins during development. SOX6 is believed to regulate embryonic development and determine cell fate. Mouse SOX6 is expressed in the CNS during embryogenesis, but this expression decreases significantly in the adult CNS. In humans, SOX6 is expressed in fetal brain and in gliomas but only at very low levels in the adult brain. A direct link between SOX6 expression and malignancy has not been demonstrated, so SOX6 probably does not promote proliferation, but it may induce transformation activity in the early stage of oncogenesis in gliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HSSOX6; SOX-LZ; SOXD; SRY (sex determining region Y)-box 6; SRY box 6; SRY-box containing gene 6; Transcription factor SOX-6
Gene Aliases: AI987981; HSSOX6; Sox-6; SOX-LZ; SOX6; SOXD