Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This antibody is specific for the ~110k monomer or the ~220k dimer of mGluR2 or mGluR3. Immunolabeling can be blocked by preadsorption of antibody with the antigenic peptide. A suggested positive control for this product is HEK-293 cell lysate.
The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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