Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-25995 detects Maf from mouse samples. PA1-25995 will not react with human.
PA1-25995 has been successfully used in chromatin immunoprecipitation, gel shift, immunohistochemistry (frozen), immunohistochemistry (paraffin), and Western blot procedures.
The PA1-25995 immunogen is a synthetic peptide corresponding to an internal domain of mouse v-maf musculoaponeurotic fibrosarcoma oncogene homolog c (Locus ID 17132) proximal to the poly-histidine domain.
c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42. c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet, p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis. c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support