PA1-26088 detects Ubiquitin from human and mouse samples.
PA1-26088 has been successfully used in immunoprecipitation, immunohistochemistry and Western blot procedures.
The PA1-26088 immunogen is full length native Ubiquitin protein purified from bovine red blood cells.
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epididymis secretory protein Li 50; Polyubiquitin B; Polyubiquitin-B; Ubiquitin; Ubiquitin B
Gene Aliases: AL033289; HEL-S-50; Rps27a; Uba52; UBB; Ubb2; Ubc