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PA1-26657 detects c-Raf (phospho Y340 + Y341) from human samples. PA1-26657 is expected to cross react with mouse and rat (both 100% conserved).
PA1-26657 has been successfully used in Western blot procedures.
The PA1-26657 immunogen is a synthetic phosphopeptide corresponding to a region of c-Raf that contains tyrosines 340 and 341.
Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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