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PA1-27918 detects HSD11B2 from human, rat, and chimpanzee samples.
PA1-27918 may be successfully used in Western blot applications. By Western blot, this antibody has only been tested on fusion protein.
The PA1-27814 immunogen is a synthetic peptide corresponding to human Corticosteroid 11-beta-dehydrogenase isozyme 2.
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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