Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-28001 detects Jagged 1 from human and rat samples.
PA1-28001 has been successfully used in flow cytometry, neutralization, Western blot and ELISA applications.
The PA1-28001 immunogen is recombinant rat jagged-1 extracellular domain expressed in mouse NSO cells.
NOTE: Endotoxin level is < 10 ng per mg antibody as determined by the LAL method.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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