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PA1-29915 detects PNK from human samples.
PA1-29915 has been successfully used in Western blot applications.
The PA1-29915 immunogen is: Peptide with sequence EPRLGRLYCQFSEG, from C Terminus of the protein sequence according to NP_009185.
Anti-human Polynucleotide Kinase Mouse Monoclonal Antibody recognizes polynucleotide kinase (PNK), a 57 kDa nuclear enzyme implicated in DNA strand repair processes that occur during DNA replication and recombination, or in response to DNA damaging agents. PNK targets the DNA 5'-hydroxy and 3'-phosphate termini for phosphorylation and dephosphorylation events. During strand breakage in human cells, normal PNK associates with other nuclear proteins to prepare the DNA termini for the enzymatic actions of DNA polymerase-beta and DNA ligase III. PNK is a key functional component in maintaining the genetic stability of human cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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