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Recommended positive controls: HepG2, human fetal heart, human fetal liver, human fetal lung, human fetal muscle, human heart, human placenta.
Predicted reactivity: Cow: 92%; Dog: 92%; Guinea Pig: 92%; Horse: 92%; Mouse: 79%; Rabbit: 85%; Rat: 92%; Sheep: 85%.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor involved in organ development and differentiation of the endocrine system. SF-1 has been shown to be essential for fetal development of the hypothalamus, pituitary gland, gonads, and the adrenal gland. SF-1 has been shown to promote transcriptional activity of many steroidogenic enzymes from the cytochrome P450 family. SF-1 contains two activation function domains, designated AF1 and AF2, common to many nuclear steroid receptors which have been shown to be necessary for interaction with other nuclear receptors as well as coactivators and corepressors including steroid receptor coactivator-1 (SRC-1), glucocorticoid receptor interacting protein 1 (GRIP1), cAMP response element binding protein (CREB) binding protein (CBP) and silencing mediator of retinoid acid and thyroid hormone receptor (SMRT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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