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Working Concentration: 1/8K. Sensitivity: 10 ng/mL Oxycodone produces 39% inhibition in a competitive ELISA employing Oxycodone (N) polyclonal antibody.
Oxycodone is a semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. [National Center for Biotechnology Information. PubChem Compound Database; CID=5284603].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C18H21NO4; Dihydrohydroxycodeinone; Dihydrone; Dihydroxycodeinone; Oxycodeinone; Oxycontin
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