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PA1-85242 reacts with des arg9 Bradykinin and shows 37% cross-reactivity with kallidin and less than 1% with TRH, LHRH, beta-endophin, GRF, CRF, and ACTH (aa 1-39).
Reconstitute with 50 µL of distilled water. Prior to reconstitution, store at 4ºC. After reconstitution, store undiluted at -20ºC, avoiding freeze/thaw cycles.
Rabbit anti DES Arg9 Bradykinin antibody recognizes des Arg9-bradykinin and exhibits 65% cross reactivity with bradykinin, 37% with kallidin and less than 1% with TRH, LHRH, beta-endorphin, GRF, CRF and ACTH (aa 1-39).
Kininogen-1 (KNG1), also known as BDK or bradykinin, is a protein that in humans is encoded by the KNG1 gene. It is mapped to 3q27.3. The KNG1 gene uses alternative splicing to generate two different proteins - high - molecular - weight kininogen (HMWK) and low - molecular- weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, KNG1, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. In addition to that, KNG1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.
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