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PA1-906 detects inositol-hexakisphosphate kinase (IP6 kinase) from rat tissues.
PA1-906 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing IP6 kinase from rat brain extract.
PA1-906 immunizing peptide corresponds to amino acid residues 216-233 from human IP6 kinase. PA1-906 immunizing peptide (Cat. # PEP-085) is available for use in neutralization and control experiments.
The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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