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This protein is expressed in various tumor cell lines including carcinomas, myeloid or lymphoid malignancies, melanomas or prostate cancer. It is also weakly expressed in kidney and overexpressed in taxol-resistant breast cancer line MDA 435(TR) or the doxorubicin-resistant multiple myelanoma lines 8226/Dox(40) or 8226/MDR(10)V.1.
The expression of the cancer-testis antigen Taxol resistanceassociated gene-3 (TRAG-3) is associated with acquired paclitaxel (Taxol) resistance, and is expressed in a variety of cancers - e.g., breast cancer, leukemia, and melanoma. Overexpressed in taxolresistant breast cancer line MDA 435(TR) and the doxorubicinresistant multiple myelanoma lines 8226/Dox(40) and 8226/MDR (10)V. Weakly expressed in kidney. TRAG-3 is an attractive target for immunotherapy of cancer.
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